What to know
Table 4
HTC Population Profile Patient Characteristics, Rare Factor Deficiencies (excluding Factor VIII and Factor IX), Data Reported from 1/1/2012 through 3/31/2024
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| FI | FII | FV | Factors V & VIII, combined |
FVII | FX | FXI | FXIII | Alpha-2 Antiplasmin Deficiency |
PAI-1 Deficiency |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| # | (%) | # | (%) | # | (%) | # | (%) | # | (%) | # | (%) | # | (%) | # | (%) | # | (%) | # | (%) | ||
| # of patients | 564 | (100) | 145 | (100) | 739 | (100) | 27 | (100) | 3561 | (100) | 384 | (100) | 2162 | (100) | 330 | (100) | 15 | (100) | 433 | (100) | |
| Age (years) | <2 | 37 | (7) | * | * | 19 | (3) | * | * | 64 | (2) | * | * | 100 | (5) | 22 | (7) | * | * | 7 | (2) |
| 2–10 | 142 | (25) | 18 | (12) | 102 | (14) | * | * | 815 | (23) | 67 | (17) | 304 | (14) | 53 | (16) | * | * | 55 | (13) | |
| 11–19 | 152 | (27) | 56 | (39) | 261 | (35) | * | * | 1493 | (42) | 126 | (33) | 512 | (24) | 79 | (24) | * | * | 152 | (35) | |
| 20–44 | 149 | (26) | 42 | (29) | 226 | (31) | 10 | (37) | 860 | (24) | 98 | (26) | 696 | (32) | 126 | (38) | * | * | 147 | (34) | |
| 45–64 | 50 | (9) | 19 | (13) | 89 | (12) | * | * | 194 | (5) | 54 | (14) | 261 | (12) | 30 | (9) | * | * | 41 | (9) | |
| 65+ | 34 | (6) | * | * | 42 | (6) | * | * | 135 | (4) | * | * | 289 | (13) | 20 | (6) | * | * | 31 | (7) | |
| Sex† | Male | 247 | (44) | 45<8/td> | (31) | 275 | (37) | 12 | (44) | 1723 | (48) | 153 | (40) | 935 | (43) | 159 | (48) | * | * | 126 | (29) |
| Female | 317 | (56) | 100 | (69) | 464 | (63) | 15 | (56) | 1838 | (52) | 231 | (60) | 1227 | (57) | 171 | (52) | * | * | 307 | (71) | |
| Ethnicity | Hispanic, Latino/a, or Spanish origin | 66 | (12) | 36 | (25) | 118 | (16) | * | * | 798 | (22) | 91 | (24) | 261 | (12) | 78 | (24) | * | * | 73 | (17) |
| Not Hispanic, Latino/a, or Spanish origin | 471 | (84) | 103 | (71) | 583 | (79) | 26 | (96) | 2585 | (73) | 275 | (72) | 1816 | (84) | 242 | (73) | * | * | 350 | (80) | |
| Unknown | 27 | (5) | 6 | (4) | 38 | (5) | * | * | 178 | (5) | 18 | (5) | 85 | (4) | 10 | (3) | * | * | 10 | (2) | |
| Race | American Indian/Alaska Native | * | * | * | * | * | * | * | * | 23 | (1) | * | * | * | * | * | * | * | * | * | * |
| Asian | 22 | (4) | * | * | 18 | (2) | * | * | 124 | (3) | 24 | (6) | 89 | (4) | 28 | (8) | * | * | 7 | (2) | |
| Black or African American | 35 | (6) | * | * | 25 | (3) | * | * | 629 | (18) | 41 | (11) | 93 | (4) | 29 | (9) | * | * | 38 | (9) | |
| Native Hawaiian or other Pacific Islander | * | * | * | * | * | * | * | * | 11 | (0) | * | * | * | * | * | * | * | * | * | * | |
| White | 441 | (78) | 118 | (81) | 625 | (85) | 17 | (63) | 2340 | (66) | 275 | (72) | 1802 | (83) | 236 | (72) | * | * | 351 | (81) | |
| More than one of these | * | * | 6 | (4) | * | * | * | * | 63 | (2) | * | * | 19 | (1) | * | * | * | * | * | * | |
| Unknown | 57 | (10) | 14 | (10) | 62 | (8) | * | * | 371 | (10) | * | * | 151 | (7) | * | * | * | * | 27 | (6) | |
| Insurance Status | Insured | 545 | (97) | 137 | (94) | 723 | (98) | 25 | (93) | 3488 | (98) | 379 | (99) | 2114 | (98) | 321 | (97) | * | * | 412 | (95) |
| Uninsured | * | * | * | * | 7 | (1) | * | * | 42 | (1) | * | * | 24 | (1) | * | * | * | * | * | * | |
| Unknown | * | * | * | * | 8 | (1) | * | * | 36 | (1) | * | * | 25 | (1) | * | * | * | * | * | * | |
| History of HCV infection | Yes | 13 | (2) | 6 | (4) | 12 | (2) | * | * | 32 | (1) | 10 | (3) | 36 | (2) | 13 | (4) | * | * | * | * |
| No | 407 | (72) | 95 | (66) | 562 | (76) | 17 | (63) | 2736 | (77) | 287 | (75) | 1640 | (76) | 280 | (85) | * | * | 257 | (59) | |
| Unknown | 144 | (26) | 44 | (30) | 165 | (22) | * | * | 793 | (22) | 87 | (23) | 486 | (22) | 37 | (11) | * | * | * | * | |
| History of HIV infection | Yes | * | * | * | * | * | * | * | * | 7 | (0) | * | * | 9 | (0) | * | * | * | * | * | * |
| No | 418 | (74) | 101 | (70) | 569 | (77) | 18 | (67) | 2739 | (77) | 297 | (77) | 1680 | (78) | 291 | (88) | * | * | 259 | (60) | |
| Unknown | * | * | * | * | * | * | * | * | 815 | (23) | * | * | 473 | (22) | * | * | * | * | * | * | |
Note. This table excludes individuals with Factor VIII deficiency (hemophilia A) and Factor IX deficiency (hemophilia B). “Factors V & VIII, combined” refers to an autosomal condition, which occurs when there is a defect in a gene on one of the first 22 pairs of chromosomes called autosomes. Hemophilia A and B are X-linked conditions, which occur when there is a defect on the 23rd pair of chromosomes which determine one’s sex.
*Counts greater than zero but less than five have been suppressed to protect patient confidentiality. Additional cells may be suppressed to prevent derivation of these counts by subtraction.